528822

PARP Inhibitor XII

The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide
• 실험식(Hill 표기법): C₁₅H₁₀ClN₃O
• CAS Number: 489457-67-2
• Molecular Weight: 283.71
• MDL number: MFCD11856053
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light brown
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N
• InChI: 1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)
• InChI key: FLYGLPYJEQPCFY-UHFFFAOYSA-N

설명

일반 설명

A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC₅₀ = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

기타 정보

Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable