300270

PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
• 실험식(Hill 표기법): C₁₈H₂₆N₂O₂
• CAS Number: 129075-73-6
• Molecular Weight: 302.41
• MDL number: MFCD01866274
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥90% (HPLC)
• 형태: solid
• 효능: 40 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: off-white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
• InChI key: RVOUDNBEIXGHJY-UHFFFAOYSA-N

설명

일반 설명

A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

기타 정보

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3