528122

PI 3,4-K inhibitor, PIK-93

The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): PI 3,4-K inhibitor, PIK-93, N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide
• 실험식(Hill 표기법): C₁₄H₁₆ClN₃O₄S₂
• CAS Number: 593960-11-3
• Molecular Weight: 389.88
• MDL number: MFCD12922510
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: pale yellow
• solubility: DMSO: 50 mg/mL, pale yellow
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(C2=C(C)N=C(NC(C)=O)S2)C=C1S(NCCO)(=O)=O
• InChI: 1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
• InChI key: JFVNFXCESCXMBC-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC₅₀ = 16, 19, 39 and 64 nM for p110γ, PI 4-KIIIβ, p110α and DNA-PK, respectively). Moderately inhibits p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC₅₀ = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively) with minimal inhibition towards a panel of 36-kinases (IC₅₀ >10 µM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250 nM.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Miller, S., et al. 2010. Science327, 1638.
Fan, Q.W., et al. 2006. Cancer Cell9, 341.
Toth, B., et al. 2006. J. Biol. Chem.281, 36369.
Knight, Z.A., et al. 2006. Cell125, 733.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable