5.08508

Zonisamide

• 동의어(들): Zonisamide, AD 810, CI 912
• 실험식(Hill 표기법): C₈H₈N₂O₃S
• CAS Number: 68291-97-4
• Molecular Weight: 212.23
• MDL number: MFCD00865316
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(N)Cc1n[o]c2c1cccc2
• InChI: 1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
• InChI key: UBQNRHZMVUUOMG-UHFFFAOYSA-N

설명

일반 설명

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀ = 24.8 µM). Displays neurprotective properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

생화학적/생리학적 작용

Primary Target
Na+ and Ca2+ channels

경고

Toxicity: Harmful (C)

기타 정보

Sonsalla, P.K., et al. 2010. Exp. Neurol.221, 329.
Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07,GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H302 - H361
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable