434625

Leukotriene B₄

Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium.

• 동의어(들): Leukotriene B₄, LTB₄, 5(S),12(R)-Dihydroxy-6- cis-8- trans-10- trans-14- cis-eicosatetraenoic Acid
• 실험식(Hill 표기법): C₂₀H₃₂O₄
• CAS Number: 71160-24-2
• Molecular Weight: 336.47
• MDL number: MFCD00135630
• UNSPSC 코드: 12352211

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: oil
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: clear
• solubility: ethanol: soluble
• 배송 상태: wet ice
• 저장 온도: −70°C
• InChI: 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6+,14-10+,15-11+
• InChI key: VNYSSYRCGWBHLG-XUOUMLBJSA-N

설명

일반 설명

Potent inflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema.

Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Polymorphonuclear leukocytes

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Flammable (J)

물리적 형태

In Ethanol.

재구성

Following initial thaw, aliquot and freeze (-70°C).

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kendall, A.P., et al. 1995. Anesthesia 50, 590.
Dokter, W.H., et al. 1994. Leukemia 8, 1181.
Jedlitschky, G., et al. 1991. J. Biol. Chem.266, 24763.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225 - H319
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2