361556

GSK-3 Inhibitor IX, Control, MeBIO

The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): GSK-3 Inhibitor IX, Control, MeBIO, 1-Methyl-BIO
• 실험식(Hill 표기법): C₁₇H₁₂BrN₃O₂
• CAS Number: 710323-61-8
• Molecular Weight: 370.20
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: dark red
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC₅₀ >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC₅₀ >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Relevant kinase inactive control

Product does not compete with ATP.

Reversible: no

Target IC₅₀: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable