361555

GSK-3 Inhibitor XIII

The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): GSK-3 Inhibitor XIII, (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
• 실험식(Hill 표기법): C₁₈H₁₅N₅
• CAS Number: 404828-08-6
• Molecular Weight: 301.35
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
• InChI key: JYCUVOXSZBECAY-UHFFFAOYSA-N

설명

일반 설명

A potent and ATP-competitive inhibitor of GSK-3 (K_i = 24 nM).

An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K_i of 24 nM.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
GSK-3

Product does not compete with ATP.

Reversible: no

Target K_i: 24 nM against GSK-3

경고

Toxicity: Carcinogenic / Teratogenic (D)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Pierce, A.C., et al. 2005. J. Med. Chem.48, 1278.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1