325001

Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

• 동의어(들): Epothilone B, Synthetic, EpoB
• 실험식(Hill 표기법): C₂₇H₄₁NO₆S
• CAS Number: 152044-54-7
• Molecular Weight: 507.68
• MDL number: MFCD02101921
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to off-white
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• InChI key: QXRSDHAAWVKZLJ-PVYNADRNSA-N

설명

일반 설명

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
P-glycoprotein-expressing multidrug resistant (MDR) cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 nM for MDR CCRF-CEM/VBL100 cells

경고

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

법적 정보

Not available for sale in Germany.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable