219555

Cathepsin K Substrate II, Fluorogenic

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

• 동의어(들): Cathepsin K Substrate II, Fluorogenic
• 실험식(Hill 표기법): C₄₀H₅₀N₁₄O₁₂
• Molecular Weight: 918.91
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: bright yellow
• solubility: DMSO: 5 mg/mL
• 형광: λ_ex 320 nm; λ_em 420 nm
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Lecaille, F., et al. 2003. Biochem. J.375, 307.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable