219478

Cdk4 Inhibitor III

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Cdk4 Inhibitor III, 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
• 실험식(Hill 표기법): C₁₅H₁₂N₂O₂S
• CAS Number: 265312-55-8
• Molecular Weight: 284.33
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥90% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: black-purple
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
• InChI key: HFPLHASLIOXVGS-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Cdk4

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett.10, 461.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable