218832

Caspase-3/7 Inhibitor II

The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Caspase-3/7 Inhibitor II, Ac-DNLD-CHO
• 실험식(Hill 표기법): C₂₀H₃₁N₅O₁₀
• CAS Number: 775289-20-8
• Molecular Weight: 501.49
• MDL number: MFCD07368597
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: N([C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CC(=O)N
• InChI key: XZGUQURUQBIHMG-XUXIUFHCSA-N

설명

일반 설명

A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC₅₀ = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC₅₀ = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.

Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
caspase-3, caspase-7

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

Ac-Asp-Asn-Leu-Asp-CHO

분석 메모

Single main spot with additional trace spot by TLC

기타 정보

Yoshimori, A., et al. 2004. BMC Pharmacol.4, 7.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable