V116

Z-VAD-FMK

≥98% (TLC), solid, Caspase inhibitor

• 동의어(들): N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
• 실험식(Hill 표기법): C₂₂H₃₀FN₃O₇
• CAS Number: 187389-52-2
• Molecular Weight: 467.49
• MDL number: MFCD01074990
• UNSPSC 코드: 12352209
• NACRES: NA.77

속성

• 제품명: Z-VAD-FMK, solid
• 생물학적 소스: synthetic
• 분석: ≥98% (TLC)
• 양식: solid
• 색상: white
• solubility: DMSO: 20 mg/mL; H₂O: insoluble
• 저장 온도: −20°C
• SMILES string: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
• InChI: 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
• InChI key: MIFGOLAMNLSLGH-QOKNQOGYSA-N
• 유전자 정보: human ... CASP3(836) ; mouse ... CASP3(12367) ; rat ... CASP3(25402)

설명

일반 설명

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

애플리케이션

Z-VAD-FMK has been used:

• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
• to induce autophagy in Jurkat and K562 cells
• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

생화학적/생리학적 작용

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)