264155

Caspase-3 Inhibitor II

The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
• 실험식(Hill 표기법): C₃₀H₄₁FN₄O₁₂
• CAS Number: 210344-95-9
• Molecular Weight: 668.66
• MDL number: MFCD23380217
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥90% (TLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white to slightly brown
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC
• InChI: 1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
• InChI key: GBJVAVGBSGRRKN-JYEBCORGSA-N

설명

일반 설명

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

서열

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable