203734-M

Brevetoxin PbTx-3, Ptychodiscus brevis

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida.

• 동의어(들): Brevetoxin PbTx-3, Ptychodiscus brevis, Pumiliotoxin, Dihydrobrevetoxin B
• 실험식(Hill 표기법): C₅₀H₇₂O₁₄
• CAS Number: 85079-48-7
• Molecular Weight: 897.10
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: >95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• solubility: ethanol: 10 mg/mL; DMSO: 30 mg/mL; acetonitrile: 30 mg/mL; chloroform: 30 mg/mL; methanol: 30 mg/mL; water: sparingly soluble
• 저장 온도: −20°C
• InChI: 1S/C50H72O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,26,28-42,44-45,51-52H,1,11-15,17-24H2,2-8H3/b10-9-
• InChI key: BKMHDYJRAAJTAD-KTKRTIGZSA-N

설명

일반 설명

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.

생화학적/생리학적 작용

Primary Target
Voltage-dependent Na+ channel activator

경고

Toxicity: Highly Toxic (H)

재구성

Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use PTFE or silicon pipette tips.

기타 정보

Baden, D.G., et al. 1994. Nat. Toxins2, 212.
Rein, K., et al. 1994. J. Org. Chem.59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300,H410
• 예방조치 성명서: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable