182540-M

Aromatase Inhibitor I

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

• 동의어(들): Aromatase Inhibitor I, 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
• 실험식(Hill 표기법): C₁₇H₁₁N₃O₄
• CAS Number: 331684-05-0
• Molecular Weight: 321.29
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 25 mg/mL
• 저장 온도: −20°C

설명

일반 설명

A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC₅₀ = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.

A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC₅₀ = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).

생화학적/생리학적 작용

Primary Target
P450 arom.

Target IC₅₀: 40 nM against P450arom

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Recanatini, M., et al. 2001. J. Med. Chem.44, 672.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable