14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

• UNSPSC 코드: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: mouse
• Quality Level: 100; 300
• 재조합: expressed in baculovirus infected Sf21 cells
• 분자량: M_w 129 kDa (p110α; H1047R); M_w 83.6 kDa (p85α)
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• NCBI 수납 번호: NM_006218.2
• UniProt 수납 번호: P42336
• 유전자 정보: mouse ... PIK3CA(18706)

설명

일반 설명

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.

Product Source: Coexpressed by baculovirus in Sf21 insect cells.

The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

애플리케이션

Research Category
Inflammation & Immunology

생화학적/생리학적 작용

Protein Target: PI3Kα/p85α

Target Sub-Family: PI3K/PI4K

포장

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

물리적 형태

Ni²⁺/NTA-agarose

저장 및 안정성

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable