14-548-M

MSK1 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in baculovirus infected Sf21 cells
• 제품 라인: Upstate^®
• 특이 활성도: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 분자량: M_w 94 kDa
• 정제법: (Ni²⁺/NTA-agarose)
• 종 반응성: human
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• 수납 번호(accession number): (FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). ); NM_004755.2
• NCBI 수납 번호: NM_004755.2; NM_182398.1
• UniProt 수납 번호: O75582
• 관련 질환(들): metabolic disorders; cardiovascular diseases
• 유전자 정보: human ... RPS6KA5(9252)

설명

일반 설명

N-terminal His6-tagged recombinant human MSK1 residues 2-end

애플리케이션

Research Category
Metabolism

Research Sub Category
Cardiovascular Disease

Metabolic Disorders

생화학적/생리학적 작용

Protein Target: MSK1

Target Sub-Family: AGC

포장

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-548M when ordering the 250 µg size.

품질

routinely evaluated by phosphorylation of Crosstide

표적 설명

MSK1

물리적 형태

Ni²⁺/NTA-agarose

저장 및 안정성

6 months at -20°C

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1