추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in baculovirus infected Sf21 cells
형태
liquid
분자량
Mw 51 kDa
구성
mercaptoethanol, 0.1-1%
saccharose, 5-10%
제조업체/상표
Upstate®
저장 조건
(Tightly closed)
기술
activity assay: suitable (kinase)
solubility
water: soluble
NCBI 수납 번호
UniProt 수납 번호
유전자 정보
human ... GSK3B(2932)
일반 설명
Glycogen synthase kinase 3β (GSK3β) is a serine-threonine kinase that is present in most eukaryotes. The GSK3β gene is located on the human chromosome at 3q13.3. GSK3β is made up of an N-terminal β-sheet domain that is coupled to the C-terminal α-helical domain.
Research area: Cell Signaling
Research area: Cell Signaling
생화학적/생리학적 작용
Glycogen synthase kinase 3β (GSK3β) regulates glycogen metabolism via an insulin-dependent pathway. It participates in many signaling pathways including cellular processes such as cell cycle, cell proliferation, and inflammation. GSK3β mediated-negative regulation of insulin signaling pathway leads to type 2 diabetes. GSK3β functions as a tumor suppressor that represses neoplastic transformation in cells. It is an essential regulator of the Wnt/β-catenin signaling pathway. Abnormal regulation of GSK3β is associated with cardiovascular disease, bipolar disorder, and neurodegenerative diseases.
포장
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-306M when ordering the 250μg size.
품질
Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2
기타 정보
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
관련 제품
제품 번호
설명
가격
억제제
제품 번호
설명
가격
항체
제품 번호
설명
가격
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase
Xu, J., et al
The Journal of Biological Chemistry, 278, 26929-26937 (2003)
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
Sutherland, C and Cohen, P
Febs Letters, 338, 37-42 (1994)
rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Dajani R, et al.
Cell, 105(6), 721-732 (2009)
Regulation and functions of the glycogen synthase kinase-3 subfamily.
Woodgett, J R
Seminars in cancer biology, 5, 269-275 (1994)
Mark S Wainwright et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(10), 6233-6238 (2003-05-06)
Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule therapeutics. Prevailing hypotheses identify endothelial cell (EC) layer dysfunction as a cardinal event
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