09-126

Anti-Tribbles-1 Antibody

Upstate^®, from rabbit

• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 제조업체/상표: Upstate^®
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NP_079471
• UniProt 수납 번호: Q96RU8
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TRIB1(10221)

설명

일반 설명

The Tribbles family of proteins are kinase-like proteins that contain a kinase-like domain, but lack either a catalytic domain or a protein-protein interaction domain (2). They are believed to regulate signal processing for various pathways including MAPK, Akt, and NFkB that are involved in various aspects of development, diabetes, and cancer (1,2,3). Their involvement has been reported to regulate a number of pathways that include mitosis, cell activation, and apoptosis. They are are a family made up of three family members. Tribbles-1 (TRIB1, SKIP1, G-protein-coupled receptor induced protein, and phosphoprotein regulated by mitogenic pathways) is a modulator of MAPK action. It has been shown to directly interact with the upstream kinases MEK1 and MKK4 of Erk and JNK, respectively(1). Tribble-2 (Trib2, TRB2) has been shown to interact with Akt(2). Tribbles-3 (TRIB3, TRB3. NIPK, SKIP3) has been shown to interact with Akt and the transcription factors ATF4 and NFkB p65 (RelA). It is interaction with RelA is thought to be negative regulation. Interestingly, it has been reported to regulate Akt activation via insulin(3).

특이성

Tribbles-1

면역원

KLH-conjugated sythetic linear peptide directed against a region of the N-terminal portion of Tribbles-1.

애플리케이션

This Anti-Tribbles-1 Antibody is validated for use in IH, WB for the detection of Tribbles-1.

품질

routinely evaluated by western blot on lysate from HeLa cells

표적 설명

41 kDa

물리적 형태

100 μg in 100μL of affinity purified rabbit serum in storage buffer containing PBS with 0.05% sodium azide.

분석 메모

Control
HeLa

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable