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Merck
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Key Documents

07-383

Sigma-Aldrich

Anti-Akt3/PKBγ Antibody

Upstate®, from rabbit

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모든 사진(1)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

100

항체 형태

affinity purified immunoglobulin

항체 생산 유형

primary antibodies

클론

polyclonal

정제법

affinity chromatography

종 반응성

human

제조업체/상표

Upstate®

기술

immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG

NCBI 수납 번호

NM_005465

UniProt 수납 번호

Q9Y243

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... AKT3(10000)

특이성

Recognizes Akt3/PKBγ.

면역원

peptide corresponding to amino acids 119-131 of human Akt3/PKBgamma

애플리케이션

Anti-Akt3/PKBγ Antibody is an antibody against Akt3/PKBγ for use in IP & WB.

품질

routinely evaluated by immunoprecipitating active Akt3/PKBγ from IGF-I stimulated HEK293 cell lysates.

표적 설명

~60 kDa

결합

Replaces: AB3136

물리적 형태

Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

분석 메모

Control
IGF-I stimulated HEK293 cell lysates

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

시험 성적서(COA)

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문서 라이브러리 방문

Anna Joy et al.
Journal of neuro-oncology, 130(1), 43-52 (2016-10-21)
The growth factor receptor/PI3K/AKT pathway is an important drug target in many cancers including Glioblastoma. AKT, a key node in the pathway, has 3 isoforms, AKT1, AKT2 and AKT3. Here we investigate their role in GBM. We find each activated
Chad R Schultz et al.
Molecular cancer, 11, 20-20 (2012-04-07)
The current treatment regimen for glioma patients is surgery, followed by radiation therapy plus temozolomide (TMZ), followed by 6 months of adjuvant TMZ. Despite this aggressive treatment regimen, the overall survival of all surgically treated GBM patients remains dismal, and
J Okano et al.
The Journal of biological chemistry, 275(40), 30934-30942 (2000-07-26)
Overexpression of epidermal growth factor receptor (EGFR) in certain cancers is well established. There is growing evidence that epidermal growth factor (EGF) activates Akt/protein kinase B (PKB) in a phosphoinositide 3-OH kinase (PI3K)-dependent manner, but it is not yet clear
Conrad P Hodgkinson et al.
Biochemistry, 41(32), 10351-10359 (2002-08-07)
Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine
Jingjing Wu et al.
Molecular medicine reports, 20(4), 3233-3239 (2019-08-23)
Homoharringtonine (HHT) and imatinib have a synergistic effect in the clinical treatment of chronic myeloid leukemia (CML). The purpose of the present study was to explore the underlying mechanisms by which HHT enhanced imatinib sensitivity. K562 CML cells were treated
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