추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
mouse, human, bovine, canine
기술
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... NOX1(27035)
관련 카테고리
일반 설명
NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
면역원
Peptide with sequence C-DKATDIVTGLKQK, from the internal region of the protein sequence according toNP_008983.2; NP_39249.1
애플리케이션
Anti-NOX1 antibody produced in goat has been used for Western blotting.
생화학적/생리학적 작용
NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Hyehun Choi et al.
Free radical biology & medicine, 101, 413-423 (2016-11-14)
Leucine Rich Repeat Containing 8A (LRRC8A) is a required component of volume-regulated anion channels (VRACs). In vascular smooth muscle cells, tumor necrosis factor-α (TNFα) activates VRAC via type 1 TNFα receptors (TNFR1), and this requires superoxide (O2•-) production by NADPH
Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning
Shuxia Jiang
Cardiovascular Research, 102(1) (2014)
NADPH oxidases in Parkinson?s disease: a systematic review
Karim Belarbi
Molecular Neurobiology, 12(84) (2017)
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Lula L
Arteriosclerosis, Thrombosis, and Vascular Biology, 24(4) (2004)
Shuxia Jiang et al.
Cardiovascular research, 102(1), 79-87 (2014-02-07)
Ischaemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and associated signalling events have
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