SAB4200227

Anti-NOX1 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• 동의어(들): Anti-GP91-2, Anti-MOX1, Anti-NADPH oxidase 1, Anti-NOH-1, Anti-NOH1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~72 kDa
• 종 반응성: human
• 농도: ~1.5 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-10 μg/mL using using human colon; western blot: 1.5-3.0 μg/mL using using HT29 cell extracts
• UniProt 수납 번호: Q9Y5S8
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... NOX1(27035)

설명

일반 설명

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1) belongs to the family of NADPH oxidases. It is abundantly expressed in colon, primarily in differentiated epithelial cells. NOX1 has two cytosolic regulators, NOXA1 and NOXO1 as well as Ras-related protein Rac1.

면역원

synthetic peptide corresponding to the N-terminal of human NOX1 isoform long (NOX1L). The corresponding sequence is identical in human NOX1 isoform long variant (NOX1LV) and highly conserved in mouse and rat NOX1 (76% sequence identity).

애플리케이션

Anti-NOX1 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

생화학적/생리학적 작용

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1) catalyzes the generation of superoxide ion. It is mitogenic and a potent trigger of the angiogenic switch, increasing the vascularity of tumors and inducing molecular markers of angiogenesis.. NOX1 promotes neurotoxic activation of microglia suggesting, that they play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS).

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable