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Merck
모든 사진(3)

Key Documents

PLA0230

Sigma-Aldrich

Rabbit anti-Beta-catenin Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

동의어(들):

88kDa, CTNNB, MRD19, armadillo, beta 1, beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein)

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

항체 형태

affinity purified immunoglobulin

항체 생산 유형

primary antibodies

Grade

Powered by Bethyl Laboratories, Inc.

종 반응성

human, mouse

기술

ChIP: 4-30 μg
immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

수납 번호(accession number)

NP_001895.1

응용 분야

research pathology

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

면역원

The epitope recognized by PLA0230 maps to a region between residue 760 and 781 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).

물리적 형태

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

기타 정보

Beta-catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta-catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta-catenin is stabilized and accumulates in the cell. Translocation of stabilized beta-catenin allows its association with transcription factors and the activation of specific gene expression.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Elsenoor J Klaver et al.
JCI insight, 6(24) (2021-11-17)
The genetic bases for the congenital disorders of glycosylation (CDG) continue to expand, but how glycosylation defects cause patient phenotypes remains largely unknown. Here, we combined developmental phenotyping and biochemical studies in a potentially new zebrafish model (pmm2sa10150) of PMM2-CDG
Naushad Ali et al.
Scientific reports, 10(1), 10578-10578 (2020-07-01)
Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms that regulate the decision between normal injury repair and neoplastic initiation are unclear. Doublecortin-like kinase 1 (DCLK1), a tumor stem cell marker, is induced
Livia M Mermejo et al.
Clinical endocrinology, 81(4), 503-510 (2014-04-11)
The role of planar cell polarity (Wnt/PCP) and calcium-dependent (Wnt/Ca) noncanonical Wnt pathways in adrenocortical tumours (ACTs) is unknown. To investigate the gene expression of Wnt/PCP and Wnt/Ca pathways and its association with TP53 p.R337H and CTNNB1 mutations in paediatric
Catherine M Willis et al.
PloS one, 9(8), e103966-e103966 (2014-08-05)
Expression of the glycosaminoglycan chondroitin sulfate-E (CS-E) is misregulated in many human cancers, including breast cancer. Cell-surface associated CS-E has been shown to have pro-tumorigenic functions, and pharmacological treatment with exogenous CS-E has been proposed to interfere with tumor progression

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