04-1545

Anti-RARα Antibody, clone 9α-9A6

ascites fluid, clone 9α-9A6, from mouse

• 동의어(들): Nuclear receptor subfamily 1 group B member 1, Retinoic acid receptor, alpha polypeptide, nucleophosmin-retinoic acid receptor alpha fusion protein, NPM-RAR long form, retinoic acid receptor, alpha
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: 9α-9A6, monoclonal
• 종 반응성: human
• 기술: immunocytochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_000955.1
• UniProt 수납 번호: P10276
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RARA(5914)

설명

일반 설명

Retinoic acid receptor alpha (RARa) is a nuclear receptor encoded by the RARA gene. This gene is sometimes referred to as NR1B1 (nuclear receptor subfamily 1, group B, member 1). RARa is a member of the steroid/thyroid superfamily of nuclear receptor proteins that regulate gene expression by binding to RNA and other elements of DNA response. As implied by its name, this protein is a receptor for retinoic acid, a metabolite of vitamin A. Retinoic acid is necessary for normal organogenesis, but can act as a teratogen when present at high levels during embryonic and fetal development. During fetal and embryonic development retinoic acid regulates transcription through the activation of nuclear receptors, specifically the Retinoic Acid Receptor (RAR). Signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. There are three isoforms associated with RAR; RARα, RARβ and RARγ.

특이성

Homology to mouse and rat is 91%.

This antibody recognizes RARα.

면역원

Epitope: Unknown

Recombinant protein corresponding to human RARα.

애플리케이션

Anti-RARα Antibody, clone 9α-9A6 is a Mouse Monoclonal Antibody for detection of RARα also known as Retinoic acid receptor alpha polypeptide & has been validated in WB, ICC.

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected RARα in HeLa and A431 cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

품질

Evaluated by Western Blot in HL60 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected RARα on 10 µg of HL60 cell lysate.

표적 설명

58 kDa observed

물리적 형태

Unpurified

Unpurified mouse monoclonal IgG1κ ascites with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

분석 메모

Control
HL60 cell lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable