S-011

Sibutramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 동의어(들): Sibutramine hydrochloride monohydrate, 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil
• 실험식(Hill 표기법): C₁₇H₂₆ClN · HCl
• CAS Number: 84485-00-7
• Molecular Weight: 316.31
• EC Number: 200-659-6
• MDL number: MFCD04039806
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329824413
• NACRES: NA.24

속성

• Grade: certified reference material
• 형태: liquid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 1.0 mg/mL in methanol (as free base)
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: clinical testing
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2
• InChI: 1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2
• InChI key: KFNNPQDSPLWLCX-UHFFFAOYSA-N
• 유전자 정보: human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

설명

일반 설명

Sibutramine, a SNRI and anorectant, was marketed as a treatment for obesity until 2010 when it was removed from the market over concerns of potential adverse cardiovascular side effects. Sold under trade names Reductil, Meridia^®, and Subitrex, this sibutramine Snap-N-Spike^® reference solution is applicable for use in LC/MS or GC/MS applications for clinical toxicology and forensic analysis.

생화학적/생리학적 작용

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Meridia is a registered trademark of Abbott Laboratories Corp.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup