L-010

Levomethorphan

vial of 10 mg, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₁₈H₂₅NO
• CAS Number: 125-70-2
• Molecular Weight: 271.40
• EC Number: 204-751-7
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: certified reference material
• 형태: solid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: vial of 10 mg
• 제조업체/상표: Cerilliant^®
• 약물 제어: USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: forensics and toxicology
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: COc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3C)c2c1
• InChI: 1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1
• InChI key: MKXZASYAUGDDCJ-CGTJXYLNSA-N

설명

일반 설명

A Certified Reference Material suitable for use in LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic analysis. Levomethorphan, the l-enantiomer of methorphan, is an opioid analgesic.

애플리케이션

• Enantioselective analysis of Levomethorphan: Development of a novel enantioselective high-performance liquid chromatography-mass spectrometry method for the differentiation of dextro- and levo-methorphan and their O-demethylated metabolites in human blood, applicable to post-mortem samples, highlighting its role in forensic toxicology (Jorbenadze et al., 2024).


• Quantitative determination in forensic samples: An enantioselective high-performance liquid chromatography-tandem mass spectrometry method was developed for the quantitative determination of methorphan and its O-demethylated metabolite in human blood, demonstrating Levomethorphan′s application as a reference standard in post-mortem forensic analysis (Lo Faro et al., 2023).


• Chiral analysis in human hair: A study on chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry, providing insights into their presence and metabolism in biological samples (Ji et al., 2022).


• Chiral purity determination: Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan using a dual selector system and quality by design methodology, enhancing the analytical capabilities for Levomethorphan (Krait et al., 2018).


• Metabolic study on chiral drugs: A metabolic study on the biochemical effects of chiral illegal drugs, including Levomethorphan, in rats using (1)H-NMR spectroscopy, contributing to understanding its biochemical behavior and potential impacts (Fukuhara et al., 2017).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable