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Merck
모든 사진(1)

주요 문서

A-060

Supelco

Amiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

실험식(Hill 표기법):
C25H30ClI2NO3
CAS Number:
Molecular Weight:
681.77
EC Number:
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

certified reference material

Quality Level

양식

liquid

특징

SNAP-N-SPIKE®, SNAP-N-SHOOT®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

농도

1.0 mg/mL in methanol (as free base)

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

clinical testing

형식

single component solution

저장 온도

−20°C

SMILES string

Cl.CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3

InChI

1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

InChI key

ITPDYQOUSLNIHG-UHFFFAOYSA-N

유전자 정보

human ... KCNH2(3757)

일반 설명

Amiodarone, marketed as Pacerone®, Cordarone®, Aratac, and Atlansil, is an antiarrhythmic agent monitored by clinical labs using HPLC or LCMS to ensure patients remain within the drugs therapeutic range.

애플리케이션


  • Amiodarone Hydrochloride in Atrial Fibrillation: For treating paroxysmal atrial fibrillation, utilizing Amiodarone HCl as a control for arrhythmic events during treatment, highlighting its pivotal role in managing cardiac arrhythmias (Metzner et al., 2024).

  • Targeted Drug Delivery Research: Amiodarone is used in targeted therapy that enhances the drug′s effectiveness and reduces systemic side effects, particularly in treating cardiac conditions (Zahid et al., 2023).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Cordarone is a registered trademark of Sanofi S.A.
Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Melissa K Passarelli et al.
Analytical chemistry, 87(13), 6696-6702 (2015-05-30)
Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiarrhythmic agent amiodarone, a phospholipidosis-inducing

문서

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need for high-speed chromatographic assays along with simplified sample preparation methods.

The benefit of HILIC over traditional reversed-phase chromatography is two-fold for both sample introduction and analyte detection. First, the high acetonitrile concentration of HILIC mobile phases allows for direct analysis of precipitated plasma samples without the need for additional sample solvent exchange. Second, the high acetonitrile content provides increased analyte response in positive ESI MS detection.

프로토콜

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

Chromatograms

application for HPLCapplication for HPLCapplication for HPLC

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