추천 제품
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 200 mg (860052P-200mg)
pkg of 1 × 25 mg (860052P-25mg)
제조업체/상표
Avanti Research™ - A Croda Brand 860052P
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
InChI
1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1
InChI key
VODZWWMEJITOND-NXCSZAMKSA-N
일반 설명
Ceramides comprise sphingoid base attached to fatty acyl chain by an amide bond. They vary in length, saturation and hydroxylation of the fatty acid chain and sphingoid base. Ceramides are synthesized by sphingomyelinase in salvage and de novo synthesis pathway. In brain, ceramide synthases mediate the synthesis of ceramides.
애플리케이션
Ceramide (Brain) has been used as a lipid standard
- in ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS)
- in liquid chromatography with a hydrophilic interaction column
- in liposome preparation to test it effect on human α–synuclein aggregation
생화학적/생리학적 작용
Ceramides are signaling molecules which play a key role in cellular events. Ceramides promote β-amyloid synthesis and induce neuronal death. Ceramide levels are associated with pathogenesis of many disease states. Impairment of ceramide metabolism is implicated in Parkinson′s and Alzheimer′s disease. High levels of ceramide is also associated with depression.
포장
5 mL Amber Glass Screw Cap Vial (860052P-200mg)
5 mL Amber Glass Screw Cap Vial (860052P-25mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
James P Madigan et al.
Experimental cell research, 388(2), 111860-111860 (2020-01-24)
There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have
Ceramide and its related neurochemical networks as targets for some brain disorder therapies
Brodowicz J, et al.
Neurotoxicity Research, 33(2), 474-484 (2018)
Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
Barrier L, et al.
International Journal of Alzheimer's Disease, 2011 (2011)
Astrocytic ceramide as possible indicator of neuroinflammation
de Wit NM, et al.
Journal of Neuroinflammation, 16(1), 48-48 (2019)
Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics
Hines K M, et al.
Journal of Lipid Research, 58(4), 809-819 (2017)
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