추천 제품
형태
powder
포장
pkg of 1 × 10 mg (860518P-10mg)
pkg of 1 × 5 mg (860518P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1
InChI key
VODZWWMEJITOND-NXCSZAMKSA-N
일반 설명
C18 Ceramide (d18:1/18:0) synthesis is catalyzed by ceramide synthase (CERS) 1 and 5. It is a component of cellular membrane and has low gel forming ability compared to unsaturated ceramide.
애플리케이션
C18 Ceramide (d18:1/18:0) has been used:
- to induce apoptosis in Manduca embryonic cell line (MRRL-CH1)
- as a standard to quantify ceramide from liver tissue using liquid chromatography-mass spectrometry
- to inhibit ceramidase in human embryonic kidney cells (HEK29) with β-glucocerebrosidase (GCase) mutation
생화학적/생리학적 작용
C18 Ceramide based derivatives are present in low levels during neurodegeneration. It favors endoplasmic reticulum based stress and autophagy in glioma cells. Low levels of C18-ceramide are implicated in human head and neck squamous cell carcinoma. C18 ceramide may inhibit tumor progression.
포장
5 mL Amber Glass Screw Cap Vial (860518P-10mg)
5 mL Amber Glass Screw Cap Vial (860518P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
또한 이 제품과 함께 일반적으로 구입
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Acid ceramidase inhibition ameliorates alpha-synuclein accumulation upon loss of GBA1 function
Human Molecular Genetics, 27(11), 1972-1988 (2018)
Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
The Journal of biological chemistry, 279(43), 44311-44319 (2004)
Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
Testing, 8(61), 104022-104022 (2017)
Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta
Journal of Lipid Research, 45(7), 1221-1231 (2004)
Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2753-2760 (2011)
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