857393P

THI

2-acetyl-5-tetrahydroxybutyl imidazole, powder

• 동의어(들): 2-acetyl-4-tetrahydroxybutyl imidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole; 2-ATHBI
• 실험식(Hill 표기법): C₉H₁₄N₂O₅
• CAS Number: 94944-70-4
• Molecular Weight: 230.22
• MDL number: MFCD18427707
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >98% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (857393P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 857393P
• 지질 유형: sphingolipids; bioactive lipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [nH]1c(ncc1[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)C
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• InChI key: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

설명

일반 설명

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

생화학적/생리학적 작용

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

포장

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable