T6330

THI

• 동의어(들): 2-ATHBI, 2-Acetyl-4-tetrahydroxybutyl Imidazole; 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
• 실험식(Hill 표기법): C₉H₁₄N₂O₅
• CAS Number: 94944-70-4
• Molecular Weight: 230.22
• MDL number: MFCD08752516
• UNSPSC 코드: 12352211
• PubChem Substance ID: 329826636
• NACRES: NA.77

속성

• 형태: powder
• Quality Level: 100
• 색상: white to light brown
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• InChI key: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

설명

생화학적/생리학적 작용

2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.

THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

제조 메모

THI is soluble in DMSO at a concentration that is greater than 5 mg/ml.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable