830843P

10:0 PA

1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt), powder

• 동의어(들): PA(10:0/10:0)
• 실험식(Hill 표기법): C₂₃H₄₄O₈PNa
• CAS Number: 321883-64-1
• Molecular Weight: 502.55
• UNSPSC 코드: 51191904
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 형태: powder
• 포장: pkg of 1 × 25 mg (830843P-25mg); pkg of 1 × 500 mg (830843P-500mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 830843P
• 지질 유형: cardiolipins; phospholipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@@](COP([O-])(O)=O)(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O.[Na+]
• InChI: 1S/C23H45O8P.Na/c1-3-5-7-9-11-13-15-17-22(24)29-19-21(20-30-32(26,27)28)31-23(25)18-16-14-12-10-8-6-4-2;/h21H,3-20H2,1-2H3,(H2,26,27,28);/q;+1/p-1/t21-;/m1./s1
• InChI key: YVHWEENUNNUSBE-ZMBIFBSDSA-M

설명

일반 설명

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

애플리케이션

10:0 PA may be used:

• as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission
• to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to activate protein kinase C (PKC)
• as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

생화학적/생리학적 작용

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

포장

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)

5 mL Clear Glass Sealed Ampule (830843P-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids