830842C

08:0 PA

1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), chloroform

• 동의어(들): PA(8:0/8:0)
• 실험식(Hill 표기법): C₁₉H₃₆O₈PNa
• CAS Number: 321883-54-9
• Molecular Weight: 446.45
• MDL number: MFCD03788001
• UNSPSC 코드: 51191904
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: liquid
• 포장: pkg of 1 × 1 mL (830842C-10mg); pkg of 1 × 2.5 mL (830842C-25mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 830842C
• 농도: 10 mg/mL (830842C-10mg); 10 mg/mL (830842C-25mg)
• 지질 유형: cardiolipins; phospholipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC)COC(=O)CCCCCCC)O
• InChI: 1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1
• InChI key: ZNDNSOYDPUTHKQ-UNTBIKODSA-M

설명

일반 설명

Phosphatidic acid (PA) is a diacyl-glycerophospholipid. Two fatty acids and a phosphate group are attached to a glycerol molecule with the help of covalent bond through ester linkage. PA can be synthesized by the activity of the endogenous enzyme phospholipase D. This prime glycerophospholipid is present in the biomembrane. 08:0 PA (1,2-dioctanoyl-sn-glycero-3-phosphate), a short chain PA is a cell-permeable analog of PA.

애플리케이션

08:0 PA has been used to induce differentiation in order to study the effects of phosphatidic acids (PAs) on the inhibition of adipogenic differentiation in 3T3-L1 preadipocytes. It may be used as a mammalian target of rapamycin (mTOR) activator in SGC-996 gall bladder carcinoma cells. It may also be used to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells.

생화학적/생리학적 작용

Phosphatidic acid (PA) serves as a precursor for phosphatidylcholine or phosphatidylserine. It plays a functional role in influencing the membrane curvature and signaling. C8-PA/08:0 PA can block its association with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAREs) to prevent the priming activity on isolated vacuoles. It also has the ability to change the proteolytic cleavage profile of Sec18.

포장

5 mL Clear Glass Sealed Ampule (830842C-10mg)

5 mL Clear Glass Sealed Ampule (830842C-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 예방조치 성명서: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• 표적 기관: Central nervous system, Liver,Kidney
• WGK: WGK 3