추천 제품
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 50 mg (700142P-50mg)
제조업체/상표
Avanti Research™ - A Croda Brand
배송 상태
dry ice
저장 온도
−20°C
InChI
1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChI key
ORNBQBCIOKFOEO-QGVNFLHTSA-N
일반 설명
Pregnenolone is a steroid hormone precursor. It is produced from cholesterol in the steroidogenic tissues, like adrenal gland, gonads and placenta.
Pregnenolone is present in adrenal gland, gonads and placenta and is synthesized form cholesterol in the presence of mitochondrial enzyme, cytochrome P450 family 11 subfamily A member 1(CYP11A1).
애플리케이션
Pregnenolone is suitable for use as a steroid standard.
생화학적/생리학적 작용
It stimulates immunosuppression. Pregnenolone also has anti-inflammatory and antifatigability properties.
Pregnenolone and its derivatives pregnenolone sulfate and allopregnenolone enhance the memory and alleviate depression improving brain cognitive functions. Pregnenolone inhibits cannabinoid receptor and associated pathway and elicits protective function during cannabis intoxication. It plays neuroprotective role in Alzheimer′s disease(AD), schizophrenia and multiple sclerosis. Pregnenolone is a neurosteroid with memory-enhancing property. It modulates excitatory glutamatergic N-Methyl-D-aspartate (NMDA) and γ-aminobutyric acid type A receptors.
Pregnenolone serves as a precursor (inactive) for steroid hormones. Pregnenolone is involved in the synthesis of neurosteroids in the brain and its active form exists as a sulfate derivative. The complex of adrenodoxin reductase (AdR), adrenodoxin (Adx) and P450scc (P450 side chain cleavage) enzymes, mediate the conversion of cholesterol to pregnenolone in mitochondria. Pregnenolone acts as an antagonist for type-1 cannabinoid (CB1) receptor.
포장
5 mL Amber Glass Screw Cap Vial (700142P-50mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
Strushkevich N, et al.
Proceedings of the National Academy of Sciences of the USA, 108(25), 10139-10143 (2011)
The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation
Murugan S, et al.
The Journal of Biological Chemistry, 294(12), 4596-4607 (2019)
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence
Marx CE, et al.
Neuroscience, 191, 78-90 (2011)
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging
Vallee M, et al.
Brain Research Reviews, 37(1-3), 301-312 (2001)
A new derivative for oxosteroid analysis by mass spectrometry
Rigdova K, et al.
Biochemical and Biophysical Research Communications, 446(3), 762-767 (2014)
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