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700001P

Avanti

DC-Cholesterol HCl

Avanti Research™ - A Croda Brand 700001P, powder

동의어(들):

3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C32H57N2O2Cl
CAS Number:
166023-21-8
Molecular Weight:
537.26
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

형태

powder

포장

pkg of 1 × 1 g (700001P-1g)
pkg of 1 × 200 mg (700001P-200mg)
pkg of 1 × 25 mg (700001P-25mg)
pkg of 1 × 500 mg (700001P-500mg)

제조업체/상표

Avanti Research™ - A Croda Brand 700001P

응용 분야

vaccine development

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]

InChI

1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H

InChI key

ISXSJGHXHUZXNF-UHFFFAOYSA-N

일반 설명

DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid with a head group and linker moiety.
DC-Cholesterol HCl is a sterol-based transfection reagent.

애플리케이션

DC-Cholesterol HCl is suitable:
  • for the preparation of ultrasound cationic microbubbles
  • to prepare liposomes
  • for the preparation of L-glutathione (GSH), loaded proliposomes

DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies. It may also be used in liposome preparation for assessing hexokinase activity, poly (lactic-coglycolicacid) loading and in mRNA transfection studies.

생화학적/생리학적 작용

DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).
DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.

포장

20 mL Clear Glass Screw Cap Vial (700001P-1g)
20 mL Clear Glass Screw Cap Vial (700001P-500mg)
5 mL Amber Glass Screw Cap Vial (700001P-200mg)
5 mL Amber Glass Screw Cap Vial (700001P-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

또한 이 제품과 함께 일반적으로 구입

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

C Colonna et al.
International journal of pharmaceutics, 364(1), 108-118 (2008-09-09)
The aim of this work was to investigate lipid-based dried powders as transfection competent carriers capable of promoting the expression of therapeutic genes. The lipid-based vectors were prepared by combining different cationic lipids 1,2-dioleoyl-3-trimethylammoniumpropane chloride (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)
Modulation of yeast hexokinase on bio-inspired membranes
Umakoshi H and Nishida A
Biochemical Engineering Journal, 69(5), 138-143 (2012)
Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid
Lendemans DG, et al.
Journal of Pharmaceutical Sciences, 94(8), 1794-1807 (2005)
ADP-ribosylation reactions, 948-948 (2001)
Pharmaceutical Chemistry ? I, 142-142 (2003)
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