930237

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

• 동의어(들): CANDDY_MLN Tag NHS ester
• 실험식(Hill 표기법): C₁₉H₂₁Cl₂N₃O₆
• Molecular Weight: 458.29
• UNSPSC 코드: 12352209
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥95%
• 형태: powder
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1

설명

애플리케이션

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable