모든 사진(1)
About This Item
실험식(Hill 표기법):
C9H11N2O5Br
CAS Number:
Molecular Weight:
307.10
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.22
추천 제품
분석
≥90%
Quality Level
형태
powder
분자량
307.1
반응 적합성
reagent type: cross-linking reagent
저장 조건
desiccated
solubility
DMSO or DMF: soluble
작용기
NHS ester
bromo
배송 상태
ambient
저장 온도
2-8°C
SMILES string
O=C(CCC1=O)N1OC(CCNC(CBr)=O)=O
InChI
1S/C9H11BrN2O5/c10-5-6(13)11-4-3-9(16)17-12-7(14)1-2-8(12)15/h1-5H2,(H,11,13)
InChI key
WGMMKWFUXPMTRW-UHFFFAOYSA-N
일반 설명
SBAP is a sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker. The reagent′s NHS ester reacts with primary amines at pH 7-9 to form stable amide bonds, and the bromacetyl reacts with sulfhydryl groups at pH >7.5 to form stable thioether bonds This reagent is useful for preparing cyclic peptides and peptide conjugates because the spacer maintains peptide-like character in the crosslinked species.
특징 및 장점
- Reactive groups: NHS ester and bromoacetyl
- Reactive toward: amino and sulfhydryl groups
- NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
- Bromacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bonds
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO)
- Spacer maintains peptide-like character in the crosslinked species
- Resulting crosslink is susceptible to acid hydrolysis
- Useful for preparing cyclic peptides and peptide conjugates
주의사항
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
J K Inman et al.
Bioconjugate chemistry, 2(6), 458-463 (1991-11-01)
A new amino acid derivative, N alpha-(tert-butoxycarbonyl)-N epsilon-[N-(bromoacetyl)-beta-alanyl]-L-lysine (BBAL), has been synthesized as a reagent to be used in solid-phase peptide synthesis for introducing a side-chain bromoacetyl group at any desired position in a peptide sequence. The bromoacetyl group subsequently
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