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Merck
모든 사진(4)

문서

B8271

Sigma-Aldrich

Bromoacetic acid N-hydroxysuccinimide ester

≥95%, powder

동의어(들):

2,5-Dioxopyrrolidin-1-yl 2-bromoacetate, N-Hydroxysuccinimide bromoacetate

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About This Item

실험식(Hill 표기법):
C6H6BrNO4
CAS Number:
Molecular Weight:
236.02
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NC.07

분석

≥95%

형태

powder

반응 적합성

reagent type: cross-linking reagent

solubility

acetone: 25 mg/mL
DMF: soluble

작용기

NHS ester

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O=C(N1OC(CBr)=O)CCC1=O

InChI

1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2

InChI key

NKUZQMZWTZAPSN-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.

주의사항

The bromoacetyl group is light sensitive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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문서 라이브러리 방문

N Kolodny et al.
Analytical biochemistry, 187(1), 136-140 (1990-05-15)
A method described here for conjugating synthetic peptides to carrier proteins provides a convenient method for determining peptide-to-carrier protein ratios. N-Bromoacetyl-containing peptides are reacted in situ with carrier proteins in which the disulfide bonds were reduced with tri-n-butylphosphine. At pH
M S Bernatowicz et al.
Analytical biochemistry, 155(1), 95-102 (1986-05-15)
Synthetic peptides derived from human fibrin were unidirectionally conjugated to three carrier proteins (bovine serum albumin, bovine alpha-lactalbumin, and keyhole limpet hemocyanin) by a method that employs N-succinimidyl bromoacetate. This heterobifunctional crosslinking reagent was prepared with a 79% yield in
John S Mort et al.
Methods in molecular medicine, 100, 237-250 (2004-07-29)
The use of synthetic peptides to generate rabbit polyclonal anticatabolic neoepitope antibodies that can be used to study the presence of defined proteolytic cleavage sites in aggrecan is described. Principles of peptide design and methods for preparation and characterization of

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