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Merck
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Key Documents

47625

Sigma-Aldrich

Fmoc-Glu(OtBu)-OH

≥98.0% (HPLC), for peptide synthesis

동의어(들):

Fmoc-L-glutamic acid 5-tert-butyl ester

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About This Item

실험식(Hill 표기법):
C24H27NO6
CAS Number:
Molecular Weight:
425.47
Beilstein:
3636375
EC Number:
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product name

Fmoc-Glu(OtBu)-OH, ≥98.0% (HPLC)

분석

≥98.0% (HPLC)

형태

powder

광학 활성

[α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1)

반응 적합성

reaction type: Fmoc solid-phase peptide synthesis

불순물

~4% water

응용 분야

peptide synthesis

작용기

Fmoc

저장 온도

2-8°C

SMILES string

CC(C)(C)OC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1

InChI key

OTKXCALUHMPIGM-FQEVSTJZSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Fmoc-Glu(OtBu)-OH is widely used as a building block in peptide synthesis for the protection of amine groups.

애플리케이션

Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
  • Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
  • Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.

It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry
Ingenito R, et al.
Journal of the American Chemical Society, 121(49), 11369-11374 (1999)
Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy
Shan L, et al.
International journal of nanomedicine, 10(49), 5571-5571 (2015)
Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Chang YS, et al.
Proceedings of the National Academy of Sciences of the USA, 110(36), E3445-E3454 (2013)
Linda C Weiss et al.
Nature chemical biology, 14(12), 1133-1139 (2018-11-16)
Infochemicals play important roles in aquatic ecosystems. They even modify food web interactions, such as by inducing defenses in prey. In one classic but still not fully understood example, the planktonic freshwater crustacean Daphnia pulex forms specific morphological defenses (neckteeth)
Pd (II)-catalyzed enantioselective C-H activation of cyclopropanes
Wasa M, et al.
Journal of the American Chemical Society, 133(49), 19598-19601 (2011)

문서

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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