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Merck
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Key Documents

47349

Sigma-Aldrich

Fmoc-Arg(Pbf)-OH

≥98.0% (HPLC)

동의어(들):

Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine, Nα-Fmoc-Nω-Pbf-L-arginine

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About This Item

실험식(Hill 표기법):
C34H40N4O7S
CAS Number:
Molecular Weight:
648.77
Beilstein:
8302671
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

분석

≥98.0% (HPLC)

형태

powder or crystals

광학 활성

[α]/D -5.5±1.0°, c = 1 in DMF

반응 적합성

reaction type: Fmoc solid-phase peptide synthesis

응용 분야

peptide synthesis

작용기

Fmoc

저장 온도

−20°C

SMILES string

Cc1c(C)c(c(C)c2CC(C)(C)Oc12)S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OCC3c4ccccc4-c5ccccc35)C(O)=O

InChI

1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1

InChI key

HNICLNKVURBTKV-NDEPHWFRSA-N

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일반 설명

Fmoc-Arg(Pbf)-OH is used as a building block in peptide synthesis, providing protection to specific functional groups while allowing for efficient peptide bond formation.

애플리케이션

Fmoc-Arg(Pbf)-OH is a Fmoc-protected amino acid derivative that can be used to create arginine-containing peptides. The 2,2,4,6,7-pentamethyIdlhydrobenzofuran-5-sulfonyl group (Pbf) can be easily cleaved by trifluoroacetic acid (TFA).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

The 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl group (Pbf) as arginine side chain protectant.
Carpino L A, et al.
Tetrahedron Letters, 34(49), 7829-7832 (1993)
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Backes B J, et al.
Nature Biotechnology, 18(2), 187-187 (2000)
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Noor F, et al.
Angewandte Chemie (International Edition in English), 44(16), 2429-2432 (2005)
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Tamamura H, et al.
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문서

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

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