추천 제품
Quality Level
분석
97%
형태
liquid
refractive index
n20/D 1.574 (lit.)
bp
61-63 °C/15 mmHg (lit.)
density
1.288 g/mL at 25 °C (lit.)
저장 온도
2-8°C
SMILES string
O=Cc1nccs1
InChI
1S/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3H
InChI key
ZGTFNNUASMWGTM-UHFFFAOYSA-N
일반 설명
2-Thiazolecarboxaldehyde is a thiazole aldehyde derivative. It undergoes Baylis–Hillman reaction with methyl acrylate catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane). The reaction mechanism has been studied by electrospray ionization mass spectrometry (ESI-MS).
애플리케이션
2-Thiazolecarboxaldehyde may be used as a reactant in the following syntheses:
- Benzothiazine N-acylhydrazones, having potential antinociceptive and anti-inflammatory activity.
- Thiazole-2-yl-(amino)methylphosphonate diethyl esters.
- Imino ester by reacting with L-leucine t-butyl ester hydrochloride.
Useful building block for taxane analogs.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
154.4 °F - closed cup
Flash Point (°C)
68 °C - closed cup
이미 열람한 고객
Synthesis of new thiazole-2,-4, and-5-yl-(amino) methylphosphonates and phosphinates: unprecedented cleavage of thiazole-2 derivatives under acidic conditions.
Tetrahedron, 66(45), 8661-8866 (2010)
Bioorganic & medicinal chemistry letters, 14(12), 3209-3215 (2004-05-20)
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent antitumor activity
Online mechanistic investigations of catalyzed reactions by electrospray ionization mass spectrometry: a tool to intercept transient species in solution.
European Journal of Organic Chemistry, 2008(2), 235-253 (2008)
The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry.
Current Organic Synthesis, 12(6), 830-852 (2015)
The Journal of organic chemistry, 73(8), 3094-3102 (2008-03-25)
A practical asymmetric synthesis of a highly substituted N-acylpyrrolidine on multi-kilogram scale is described. The key step in the construction of the three stereocenters is a [3+2] cycloaddition of methyl acrylate and an imino ester prepared from l-leucine t-butyl ester
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.