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Merck
모든 사진(2)

주요 문서

412449

Sigma-Aldrich

PAMAM dendrimer, ethylenediamine core, generation 4.0 solution

10 wt. % in methanol

동의어(들):

Starburst Generation 4

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About This Item

Linear Formula:
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
CAS Number:
Molecular Weight:
14214.17
MDL number:
UNSPSC 코드:
12162002
NACRES:
NA.23

설명

amino surface groups

Quality Level

양식

solution

분자량

generation 4.0

특징

core type ethylenediamine core (2-carbon core)

농도

10 wt. % in methanol

표면기 개수

64

refractive index

n20/D 1.348

bp

64.7 °C

density

0.813 g/mL at 25 °C

저장 온도

2-8°C

일반 설명

PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is a poly(amidoamine) that is categorized as a class of dendritic polymers which can be prepared by a two-step interactive reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular “branched upon branched” pattern. It is majorly used as a high capacity chelating agent.

애플리케이션

PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is used as a compacting agent to bring in the conformational changes in the DNA molecule. It can be attached on the cellulose substrate that acts as a biofunctional surface for potential applications in immonoassays. It is used in MRI contrast agents and in the condensation formation of silica nanospheres.

물리적 형태

Contains 64 surface primary amino groups

법적 정보

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

51.8 °F - closed cup

Flash Point (°C)

11 °C - closed cup

개인 보호 장비

Eyeshields, Faceshields, Gloves


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문서 라이브러리 방문

Dendrimer enhanced ultrafiltration. 1. Recovery of Cu (II) from aqueous solutions using PAMAM dendrimers with ethylene diamine core and terminal NH2 groups
Diallo MS, et al.
Environmental Science & Technology, 39(5), 1366-1377 (2005)
Rolando Alberto Rodríguez-Fonseca et al.
Colloids and surfaces. B, Biointerfaces, 177, 77-93 (2019-02-04)
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
Ainalem M, et al.
PLoS ONE, 9(3), e92692-e92692 (2014)
Kobayashi, H., et al.
Magn. Reson. in Med., 50, 758-758 (2003)
Felipe Vidal et al.
Molecular pharmaceutics, 13(10), 3395-3403 (2016-08-25)
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with

문서

Environmental concerns are driving the replacement of volatile organic solvents by water and aqueous mixtures. This change often creates challenges because many organic molecules show low water solubility.

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