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Merck
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주요 문서

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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

동의어(들):

Dichloroacetic acid sodium salt

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모든 사진(1)

About This Item

Linear Formula:
Cl2CHCO2Na
CAS Number:
2156-56-1
Molecular Weight:
150.92
EC Number:
218-461-3
MDL number:
MFCD00070489
UNSPSC 코드:
12352302
PubChem Substance ID:
24861527
NACRES:
NA.22
분석:
98%

Quality Level

100

분석

98%

불순물

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

작용기

chloro

SMILES string

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

유전자 정보

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

일반 설명

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

애플리케이션

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335,H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
STBK2573
STBK0770
STBJ8996
STBJ4103
STBJ0423

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이미 열람한 고객

Slide 1 of 3

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Sodium chloroacetate 98%

Sigma-Aldrich

291773

Sodium chloroacetate

6-Aminonicotinamide 99%

Sigma-Aldrich

A68203

6-Aminonicotinamide

Methyl dichloroacetate &#8805;99%

Sigma-Aldrich

35840

Methyl dichloroacetate

Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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