추천 제품
형태
powder
Quality Level
광학 활성
[α]25/D +159°, c = 1 in H2O
분자량
average Mn 1310
라벨링 범위
1.6-2.0 mol CH3 per unit anhydroglucose
색상
white
mp
180-182 °C (lit.)
InChI
1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
InChI key
QGKBSGBYSPTPKJ-UHFFFAOYSA-N
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일반 설명
Methyl-β-cyclodextrin (MβCD) is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilizing enzyme in organic solvents.
애플리케이션
Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Methyl-β-cyclodextrin may be used as:
- A buffer additive for the effective separation of aminophospholipids by modified micellar electrokinetic capillary chromatography (MEKC) coupled with laser-induced fluorescence detection.
- A mobile phase additive for the analysis of R,S-naproxen mixtures in commercial tablet formulations by conventional and nano-liquid chromatography (nano-LC).
- An analytical standard for the determination of the analyte in biological samples by high performance liquid chromatography (HPLC).
- A chiral selector for the resolution of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis.
기타 정보
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
368.6 °F
Flash Point (°C)
187 °C
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Controlled 2D crystallization of membrane proteins using methyl-?-cyclodextrin.
Journal of Structural Biology, 157(2), 321-328 (2007)
Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis.
Biochemical and Biophysical Research Communications, 320(1), 165-169 (2004)
Tea polyphenol epigallocatechin?3?gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti?allergic action of the catechin.
Biofactors, 21(1?4), 383-385 (2004)
Improved enzyme activity and enantioselectivity in organic solvents by methyl-?-cyclodextrin.
Journal of the American Chemical Society, 121(36), 8157-8163 (1999)
Journal of chromatographic science, 50(8), 739-743 (2012-05-24)
This study used the general applicability of 2,6-didi-o-methyl-β-cyclodextrin (DM-β-CD) as the chiral selector in capillary electrophoresis for fast and efficient chiral separation of repaglinide enantiomers. A systematic study of the parameters affecting separation was performed with UV detection at 243
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