280550
4-Diphenylmethoxy-1-methylpiperidine hydrochloride
95%
동의어(들):
4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H23NO · HCl
CAS Number:
Molecular Weight:
317.85
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
Quality Level
분석
95%
mp
203-205 °C (lit.)
작용기
ether
phenyl
SMILES string
Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3
InChI
1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
InChI key
LPRLDRXGWKXRMQ-UHFFFAOYSA-N
유전자 정보
human ... HRH1(3269)
일반 설명
4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.
애플리케이션
4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.
Gennady B Lapa et al.
European journal of pharmacology, 506(3), 237-240 (2005-01-04)
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse
M Vasudevan et al.
Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH
M A Lung et al.
Rhinology, 25(2), 95-100 (1987-06-01)
The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses
K O Ebete et al.
Journal of chromatography. B, Biomedical applications, 677(2), 319-323 (1996-03-03)
A rapid, reliable and specific reversed-phase high-performance liquid chromatographic procedure is described for the determination of diphenylpyraline hydrochloride at nanogram concentrations in plasma and urine. After extraction of the drug with n-pentane-2-propanol (50:1) from alkalinized samples, the organic extract was
Chika Hasegawa et al.
Rapid communications in mass spectrometry : RCM, 20(4), 537-543 (2006-01-19)
Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded monolithic silica gel was fixed. Human plasma (0.1
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