246611

Lithium diisopropylamide

97%

• 동의어(들): LDA
• Linear Formula: [(CH₃)₂CH]₂NLi
• CAS Number: 4111-54-0
• Molecular Weight: 107.12
• Beilstein: 3655042
• EC Number: 223-893-0
• MDL number: MFCD00064449
• UNSPSC 코드: 12352001
• PubChem Substance ID: 24854817
• NACRES: NA.22

속성

• vapor density: >1 (vs air)
• Quality Level: 100
• 분석: 97%
• 양식: solid
• density: 0.864 g/mL at 25 °C (lit.)
• 작용기: amine
• SMILES string: [Li]N(C(C)C)C(C)C
• InChI: 1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1
• InChI key: ZCSHNCUQKCANBX-UHFFFAOYSA-N

설명

일반 설명

Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran.

애플리케이션

Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds.
It can also be used as a base in:

• The direct alkylation and acylation of ketones.
• The aldol condensation reaction.
• α-Selenation reaction.
• The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds.
• The alkylation of acids, esters, amides, and nitriles.
• The initiation of anionic polymerization.

안전성 정보

• 픽토그램: GHS02,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H250,H314
• 예방조치 성명서: P231 + P232 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P370 + P378
• Hazard Classifications: Eye Dam. 1 - Pyr. Sol. 1 - Skin Corr. 1B
• 보충제 위험성: EUH014
• Storage Class Code: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 2
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges