23261

Trichloromethyl chloroformate

≥97.0% (GC)

• 동의어(들): TCF, Diphosgene, di-Phosgene
• Linear Formula: ClCOOCCl₃
• CAS Number: 503-38-8
• Molecular Weight: 197.83
• Beilstein: 970225
• EC Number: 207-965-9
• MDL number: MFCD00015553
• UNSPSC 코드: 12352108
• PubChem Substance ID: 57648028
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥97.0% (GC)
• refractive index: n20/D 1.458
• bp: 20 °C/10 mmHg (lit.)
• density: 1.639 g/mL at 20 °C
• 작용기: chloro
• 저장 온도: 2-8°C
• SMILES string: ClC(=O)OC(Cl)(Cl)Cl
• InChI: 1S/C2Cl4O2/c3-1(7)8-2(4,5)6
• InChI key: HCUYBXPSSCRKRF-UHFFFAOYSA-N

설명

애플리케이션

Reactant for preparation of:

• Cyclic carbamimidates using a monophosphine gold(i) catalyst
• N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
• Prostate-specific membrane antigen-targeted anticancer prodrugs
• Potential west nile virus protease inhibitors
• Antibody-drug conjugates (ADCs)
• Erythromycin A derivatives

Trichloromethyl chloroformate (TCF) is an effective alternative to phosgene. It can react with amines, amino acids and amino alcohols to give the corresponding isocyanates, isocyanato acid chlorides and isocyanato chloroformates.
TCF can also be used:

• To synthesize N-carboxy α-amino acid anhydrides.
• As an acylating agent to synthesize oxazolidinones from α-amino alcohols.
• As a dehydrating agent to synthesize aromatic diisocyanides in the presence of triethylamine.

기타 정보

Easy to handle substitute for phosgene; In-situ charcoal-catalyzed decomposition to phosgene and reaction with amino acids to N-carboxy anhydrides

안전성 정보

• 픽토그램: GHS06,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314,H330
• 예방조치 성명서: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Skin Corr. 1B
• Storage Class Code: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter