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Merck
모든 사진(1)

문서

185892

Sigma-Aldrich

Ethyl chloroformate

97%

동의어(들):

Chloroformic acid ethyl ester

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About This Item

Linear Formula:
ClCOOC2H5
CAS Number:
Molecular Weight:
108.52
Beilstein:
385653
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.74 (vs air)

Quality Level

vapor pressure

3.42 psi ( 20 °C)

분석

97%

형태

liquid

autoignition temp.

842 °F

refractive index

n20/D 1.395 (lit.)

bp

93 °C (lit.)

mp

−81 °C (lit.)

solubility

alcohol: miscible
benzene: miscible
chloroform: miscible
diethyl ether: miscible
water: insoluble

density

1.135 g/mL at 25 °C (lit.)

SMILES string

CCOC(Cl)=O

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

InChI key

RIFGWPKJUGCATF-UHFFFAOYSA-N

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관련 카테고리

애플리케이션

  • Ethyl chloroformate was used in the synthesis of nitrile oxides.
  • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction.
  • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography.
  • It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.
  • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

포장

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

픽토그램

FlameSkull and crossbonesCorrosion

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point (°F)

60.8 °F

Flash Point (°C)

16 °C

개인 보호 장비

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


시험 성적서(COA)

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문서 라이브러리 방문

Melanie Junge et al.
Chirality, 19(3), 228-234 (2007-01-19)
The chiral separation of amino acids (AA) derivatised with ethyl chloroformate by using comprehensive two-dimensional gas chromatography is reported. A commercially available enantioselective capillary column (Chirasil-l-Val) has been tested as first-dimension column. Two nonenantioselective stationary phases (BPX50 and BP1) with
A convenient preparative method of nitrile oxides by the dehydration of primary nitro compounds with ethyl chloroformate or benzenesulfonyl chloride in the presence of triethylamine.
Shimizu T, et al.
Bulletin of the Chemical Society of Japan, 59(9), 2827-2831 (1986)
Tetrahedron Letters, 48, 1465-1465 (2007)
M R Wright et al.
Journal of chromatography, 616(1), 59-65 (1993-06-23)
A potential problem with chiral derivatization is the possibility of stereochemical conversion during the derivatization reaction. This possibility has been examined using the non-steroidal anti-inflammatory drugs ibuprofen, ketoprofen, etodolac and flurbiprofen. To avoid possible interference from stereochemical impurities, male Sprague-Dawley
Sezin Erarpat et al.
Journal of separation science, 43(6), 1100-1106 (2019-12-21)
A green and fast analytical method for the determination of l-methionine in human plasma is presented in this study. Preconcentration of the analyte was carried out by switchable solvent liquid phase microextraction after ethyl chloroformate derivatization reaction. Instrumental detection of

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