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Merck
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Key Documents

142859

Sigma-Aldrich

Difluoroacetic acid

98%

동의어(들):

1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid

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About This Item

Linear Formula:
F2CHCO2H
CAS Number:
Molecular Weight:
96.03
Beilstein:
1098588
EC Number:
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.22

Quality Level

분석

98%

형태

liquid

refractive index

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

SMILES string

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

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일반 설명

Difluoroaceticacid is a monocarboxylic acid and an organofluorine compound. Difluoroaceticacid is easy-to-handle reagent, useful for obtaining difluoromethyl substituents. Difluoroacetic acid can be used asdifluoromethylating reagent for the direct C−H difluoromethylation ofheteroaromatic compounds.

애플리케이션

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

픽토그램

CorrosionExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

172.4 °F - closed cup

Flash Point (°C)

78 °C - closed cup

개인 보호 장비

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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문서 라이브러리 방문

N Illy et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 175(2), 242-246 (1981-01-01)
Our experiments were carried out in normal and streptozotocin-diabetic rats. The effects of sodium difluoroacetate (DFA) at the dose of 40 mg/kg daily were studied on the blood and retinal lactate levels; these effects were compared to those of an
Brian M Wagner et al.
Journal of chromatography. A, 1489, 75-85 (2017-02-19)
To facilitate mass transport and column efficiency, solutes must have free access to particle pores to facilitate interactions with the stationary phase. To ensure this feature, particles should be used for HPLC separations which have pores sufficiently large to accommodate
Tetrahedron Letters, 48, 3251-3251 (2007)
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Ute Dorgerloh et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-17)
The concentrations of difluoroacetic acid (DFA) and trifluoroacetic acid (TFA) in rainwater and surface water from Berlin, Germany resembled those reported for similar urban areas, and the TFA/DFA ratio in rainwater of 10:1 was in accordance with the literature. In

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