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Merck
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Key Documents

107425

Sigma-Aldrich

Nicotinic hydrazide

97%

동의어(들):

Nicotinic acid hydrazide

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About This Item

실험식(Hill 표기법):
C6H7N3O
CAS Number:
Molecular Weight:
137.14
Beilstein:
119299
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

분석

97%

mp

159-161 °C (lit.)

solubility

H2O: soluble 50 mg/mL

작용기

amine

SMILES string

NNC(=O)c1cccnc1

InChI

1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)

InChI key

KFUSANSHCADHNJ-UHFFFAOYSA-N

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일반 설명

Nicotinic hydrazide is a heterocyclic compound that can be used to synthesize Schiff bases.

애플리케이션

Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.

생화학적/생리학적 작용

Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.

제조 메모

Nicotinic hydrazide dissolves in water at a concentration of 50 mg/ml to form a clear, colourless solution.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

이미 열람한 고객

V Goral et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1347-1352 (2001-02-15)
Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain components to a molecular target. We present here an extension
Thermo-chemical behavior of solid nicotinic hydrazide metal complexes in correlation with their stoichiometry.
Sekkina MM and El-Azm MG.
Thermochimica Acta, 77(1), 211-218 (1984)
H A Shoeb et al.
Antimicrobial agents and chemotherapy, 27(3), 399-403 (1985-03-01)
Oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase at the expense of H2O2 yielded reactive species which were able to reduce nitroblue tetrazolium and bleach p-nitrosodimethylaniline. Nicotinic acid hydrazide oxidation did not cause these effects. At slightly alkaline pH
Alireza Moradi et al.
Archiv der Pharmazie, 343(9), 509-518 (2010-09-02)
A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti-inflammatory activity in
[Tautomerism of 2-hydrazino-4-phenylthiazole<-->4-phenylthiazol-2-one hydrazone. Derivatives of acids. II. (4-phenyl-3-R-thiazol-2-ylidene) and beta-methyl-beta-(4-phenylthiazol-2-yl) hydrazides of picolinic, nicotinic, and isonicotinic acid].
L Bielak et al.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 44, 41-51 (1989-01-01)

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